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Week 4 - Sunday, September 28, 2025
| Week | Road Team | Home Team | Day |
|---|---|---|---|
| 4 | 
SEA |
ARZ | THU |
| 4 | 
MIN |
PIT | |
| 4 | 
WAS |
ATL | |
| 4 | 
NO |
BUF | |
| 4 | 
CLE |
DET | |
| 4 | 
TEN |
HOU | |
| 4 | 
CAR |
NE | |
| 4 | 
LAC |
NYG | |
| 4 | 
PHI |
TB | |
| 4 | 
IND |
LAR | |
| 4 | 
JAC |
SF | |
| 4 | 
BAL |
KC | |
| 4 | 
CHI |
LV | |
| 4 | 
GB |
DAL | |
| 4 | 
NYJ |
MIA | |
| 4 | 
CIN |
DEN |